Your opinions are important to us. They assessed the data in terms of whether statins influenced the production of GILZ in the body. Lloyd-Jones said if you have a high risk of heart disease or stroke, it's important not to just stop taking statins and other cholesterol drugs. Newsmax, Moneynews, Newsmax Health, and Independent. "According to figures from observational studies, muscle problems have been found to occur in 5% to 29% of cases. Does this mean DuBroff thinks patients should dump their cholesterol-lowering drugs? New study says statins and other cholesterol drugs may not reduce risk of heart disease after all. or, by Saarland University. The researchers said the review of 35 randomized controlled trials failed to show a consistent benefit in lowering the risk of heart attack or stroke, or for preventing deaths. In addition, the formation of muscle fibres is inhibited," says Alexandra K. Kiemer. "The acronym GILZ stands for glucocorticoid-induced leucine zipper," explains Professor Kiemer. He's a clinical professor of medicine in the division of cardiology at the University of New Mexico's School of Medicine in Albuquerque. Neither your address nor the recipient's address will be used for any other purpose. It's Cholesterol Education Month, a good time to protect your health by sorting out the sometimes-confusing facts. They are also inexpensive. After confirming their original suspicions, the researchers were able to corroborate their hypothesis by carrying out a series of experiments on living cells. Thank you for taking your time to send in your valued opinion to Science X editors. "It's a leap of faith to think that if you lower LDL, it will bring down your cardiovascular risk and mortality. "The main function of GILZ is actually to suppress inflammatory processes in the body. Maybe we've all been brainwashed a bit into thinking that we need to take a pill and we'll be safe from cardiovascular disease.". SpaceX launches 4 astronauts to space station, beginning new era for NASA. "Statins cause an increase in the cellular production of the GILZ protein. Keep discussions on topic, avoid personal attacks and threats of any kind. "Normally, when you have a theory that says something is beneficial, it should be beneficial all the time, but not all of these studies show the benefit," said study author Dr. Robert DuBroff. Visit BBC News for up-to-the-minute news, breaking news, video, audio and feature stories. Nasa, Boeing, Bezos and Musk have a lot riding on the US election. However, that's where DuBroff diverges from the American Heart Association and the American College of Cardiology. American. Apart from any fair dealing for the purpose of private study or research, no August 4, 2020 | Tom Tillison | Print Article. Your email address is used only to let the recipient know who sent the email. He noted that most experts agree that LDL cholesterol plays a critical role in the development of plaques that stiffen blood vessels. The research team then tried switching off the GILZ protein in living cells and observing what effect the statins then had. Patients who take statins in order to lower their blood cholesterol levels often complain about muscle problems, typically muscle pain. But why this occurs is still largely unresolved. The drugs are usually well tolerated and have a low risk of side effects. The pharmaceutical researchers led by Alexandra K. Kiemer are therefore planning a new study to be conducted in collaboration with the sports medicine physician Anne Hecksteden from the research group headed by Professor Tim Meyer at Saarland University. Generally speaking, statins are well tolerated by patients. Of these 13 studies, only one saw a reduced risk of death. Total: 408; SHARE 398; TWEET 9; EMAIL 1 … "Statins are very effective at lowering LDL cholesterol [preventing it from developing into plaque that deposits on blood vessel walls]. By William Harwood November 16, 2020 / 7:59 AM / CBS News Over the years, her research group has conducted numerous experimental studies into this particular protein. The latest breaking news, comment and features from The Independent. Furthermore, the statins appear to impair the success of physical training programmes. This site uses cookies to assist with navigation, analyse your use of our services, and provide content from third parties. If the benefits of lowering cholesterol aren't clear, why are so many people taking these drugs?